Chemical Modification of Arginine with 1 ,2-Cyclohexanedione

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Chemical Modification of Arginine with 1,2-cyclohexanedione.

5. GUTFREUND, El., Trans. Faraday Sot., 61, 441 (1955). 6. WALBFI, K. A., KAUFFMAN, D. L., SAMPATH KUMAR, K. S. V., AND NEURATE, H., Proc. Natl. Ad. Sci. U. S., 51, 301 (1964). 7. WALSH, K. A., AND NEURATH, H., Proc. Nail. Acad. Sci. U. S., 52, 884 (1964). 8. MARE&GUIA, M., AND SHAW, E., Federation Proc., 22, 528 (1963). 9. CRESTFIELD, A. M., STEIN, W. H., AND MOORE, S., J. Bid. Chem., 238, 241...

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Studies on the chemical modification of arginine. I. The reaction of 1,2-cyclohexanedione with arginine and arginyl residues of proteins.

The guanido group of arginine condenses with 1, Z-cyclohexanedione in alkaline aqueous medium to form a new a-amino acid. The product (1 ,2-cyclohexanedione-arginine) was shown by independent synthesis to be N5-(4-0x0-1,3diazaspiro[4.4]non 2 ylidene) L ornithine. At hydroxide concentrations of 0.2 N or higher, this was the principal product, and the reaction with free arginine and with the argi...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1965

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)97242-x